RNDr. Vendula Hlaváčková Pospíchalová, Ph.D.
Principal Investigator
UKB A36/112
| phone: | +420 549 49 3491 |
|---|---|
| e‑mail: |
Harnessing the potential of ascites to improve outcomes for ovarian cancer patients through innovative research.
Ovarian cancer (OC) ranks among the deadliest cancers in women. Lack of symptoms, rapid metastases and common chemoresistance contribute to unfortunate fate of majority of OC patients, especially those having high-grade serous carcinoma of the ovary, fallopian tube and peritoneum (HGSC), the most common and most aggressive type of OC. Many HGSC patients have excess fluid in the peritoneum called ascites. Ascites is basically a tumor microenvironment (TME) containing various cells, proteins and extracellular vesicles (EVs).
EVs play an important role in cancerogenesis and hold great promise as disease biomarkers, yet their small size and polydispersity bring various challenges to their isolation and characterization, including method-dependent enrichment of different EV subtypes as well as contaminants.
Our research projects focus on method development in the EV field, comparison of different isolation methods and especially on proteomic analyses of ascitic EVs and how these can help in unraveling the underlying molecular principles of disease progression and how can ascites serve as a new source of diagnostic/screening/prognostic EV-based biomarkers of HGSC and clinically relevant disease models, such as organoids.
We are proud members of the International Society for Extracellular Vesicles (ISEV) and co-founders of Czech Society for Extracellular Vesicles (CzeSEV).
Principal Investigator
UKB A36/112
| phone: | +420 549 49 3491 |
|---|---|
| e‑mail: |
Total number of publications: 19
Hematological Oncology, year: 2025, volume: 43, edition: 1, DOI
CELLULAR ONCOLOGY, year: 2025, volume: 48, edition: 1, DOI
Journal of Extracellular Vesicles, year: 2024, volume: 13, edition: 2, DOI
Journal of Extracellular Vesicles, year: 2024, volume: 13, edition: 3, DOI
Theranostics, year: 2020, volume: 10, edition: 2, DOI
Scientific Reports, year: 2019, volume: 9, edition: 13211, DOI
Journal of Extracellular Vesicles, year: 2019, volume: 8, edition: 1, DOI
TRANSLATIONAL ONCOLOGY, year: 2016, volume: 9, edition: 2, DOI
Plos one, year: 2015, volume: 10, edition: 7, DOI
MOLECULAR CANCER RESEARCH, year: 2015, volume: 13, edition: 7, DOI
| MU Researcher: | RNDr. Vendula Hlaváčková Pospíchalová, Ph.D. |
|---|---|
| MU Faculty or unit: | Faculty of Science |
| Project Period: |
1/2026 — 12/2029
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| Investor: |
Ministry of Health of the CR
/
Programme NW (2024 - 2030)
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| MU Researcher: | Mgr. Ondřej Bernatík, Ph.D. |
|---|---|
| MU Faculty or unit: | Faculty of Medicine |
| Project Period: |
1/2026 — 12/2029
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| Investor: |
Ministry of Health of the CR
/
Programme NW (2024 - 2030)
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| MU Researcher: | RNDr. Vendula Hlaváčková Pospíchalová, Ph.D. |
|---|---|
| MU Faculty or unit: | Faculty of Science |
| Project Period: |
5/2025 — 12/2028
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| Investor: |
Ministry of Health of the CR
/
Programme NW (2024 - 2030)
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| MU Researcher: | MUDr. Libor Viktora |
|---|---|
| MU Faculty or unit: | Faculty of Medicine |
| Project Period: |
1/2026 — 12/2027
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| Investor: |
Masaryk University
/
Internal projects of the Faculty of Medicine
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| MU Researcher: | Bc. Hana Frindtová |
|---|---|
| MU Faculty or unit: | Faculty of Science |
| Project Period: |
3/2026 — 2/2027
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| Investor: |
Masaryk University
/
Grant Agency of Masaryk University
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| MU Researcher: | prof. RNDr. Alois Kozubík, CSc. |
|---|---|
| MU Faculty or unit: | Faculty of Science |
| Project Period: |
1/2026 — 12/2026
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| Investor: |
Masaryk University
/
Specific research - support for student projects
|
| MU Researcher: | RNDr. Vendula Hlaváčková Pospíchalová, Ph.D. |
|---|---|
| MU Faculty or unit: | Faculty of Science |
| Project Period: |
1/2025 — 12/2026
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| Investor: |
Ministry of Education, Youth and Sports of the CR
/
Mobility Activity
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| MU Researcher: | prof. RNDr. Alois Kozubík, CSc. |
|---|---|
| MU Faculty or unit: | Faculty of Science |
| Project Period: |
1/2025 — 12/2025
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| Investor: |
Masaryk University
/
Specific research - support for student projects
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| MU Researcher: | doc. Mgr. Jiří Šána, Ph.D. |
|---|---|
| MU Faculty or unit: | Faculty of Medicine |
| Project Period: |
6/2022 — 12/2025
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| Investor: |
Ministry of Education, Youth and Sports of the CR
/
national recovery plan
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| MU Researcher: | RNDr. Kamila Součková, Ph.D. |
|---|---|
| MU Faculty or unit: | Central European Institute of Technology |
| Project Period: |
5/2021 — 12/2025
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| Investor: |
Ministry of Health of the CR
/
Programme NU (2020 - 2026)
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Národní ústav pro výzkum rakoviny: K čemu jsou extracelulární vezikuly?